ea0014s16.3 | Immune-endocrine turmoil of pregnancy | ECE2007
Claudia Zenclussen Ana
, Rau Juliane
, Thuere Catharina
, Schumacher Anne
, Zimmermann Gerolf
, Volk Hans-Dieter
, Alexander Henry
The survival of the semiallogeneic fetus within the mother is thought to be due to mechanisms of immunological tolerance. Regulatory T cells (Treg) are believed to have a crucial role in maintaining pregnancy by creating a transient tolerant microenvironment within the maternal uterus as former studies confirmed. We have evidences that Treg expand in lymph nodes from normal pregnant mice already on day 2 of pregnancy. Abortion-prone mice present diminished numbers of Treg in i...